[Wikipedia] Range, Description, Toxicity, Uses: Solanum elaeagnifolium, the silverleaf nightshade[1] or silver-leaved nightshade, is a common native plant to parts of the southwestern USA, and sometimes weed of western North America and also found in South America. Solanum elaeagnifolium was described by A. J. Cavanilles. The plant described under the same name by W. Herbert and C. L. Willdenow based on E.G. von Steudel is Solanum aethiopicum. Toxicity It is toxic to both humans and livestock.[13] Ingestion of silverleaf nightshade has been implicated as a cause of ivermectin toxicosis in horses given the recommended dosage of the drug. Metabolites from the plant are speculated to disrupt the blood–brain barrier, allowing ivermectin to enter and disrupt neurotransmitter function in the brain and spinal cord.[14] Its thin spines can cause weed dermatitis.[15] The Pima Indians used the berries as a vegetable rennet, and the Kiowa used the seeds together with brain tissue to tan leather.[9] (link added by Mary Ann Machi)